Book Chapter

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1. Kidney Development, Disease, Repair and Regeneration (Edited by Melissa Little). Chapter 39 – Human Fetal Kidney for Regenerative Medicine: From Embryonic Rudiments to Renal Stem/Progenitor Cells. Klaudyna Dziedzic, Oren Pleniceanu and Benjamin Dekel. Academic Press. pp531-539 2016.

DOI:10.1016/B978-0-12-800102-8.00039-4


Peer Reviewed Publications

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1. Transcutaneous Assessment of Renal Function in Conscious Rodents. Zeneida Herrera Pérez, S Weinfurter, Norbert Gretz. Journal of Visualised Experiments. doi:10.3791/53767 (2016). In-Press.


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2. A comprehensive review on the genetic regulation of cisplatin-induced nephrotoxicity. Zeneida Herrera Pérez, Norbert Gretz, H Dweep. Current Genomics, 2015. In-Press. Accepted on 2nd November 2015.


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3. Fast glomerular quantification of whole ex vivo mouse kidneys using Magnetic Resonance Imaging at 9.4 Tesla. Jorge Chacon-Caldera, Stefania Geraci, Philipp Krämer, Luise Cullen-McEwen, John F. Bertram, Norbert Gretz, Lothar R. Schad. Zeitschrift für Medizinische Physik, 2015. In-Press. Accepted on December 2015. Published onlnie ahead of print 7 January 2016.


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4.Cystinosin deficiency causes podocyte damage and loss associated with increased cell motility. Ekaterina A. Ivanova*, Fanny Oliveira Arcolino*, Mohamed A. Elmonem, Maria Pia Rastaldi, Laura Giardino, Elisabeth Cornelissen, Lambertus P. van den Heuvel and Elena N. Levtchenko. Kidney International, Accepted on 7 january 2016. *Shared first co-authorship.


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5. The Ever–Expanding Kidney Repair Shop. Benjamin Dekel. Journal of the American Society of Nephrology. Published online ahead of print 7 December 2015.


Journal of American Society of Nephrology cover image

6.Urine of Preterm Neonates As Novel Source Of Kidney Progenitor Cells. Fanny Oliveira Arcolino, Silvia Zia, Katharina Held, Elli Papadimitriou, Koen Theunis, Benedetta Bussolati, Anke Raaijmakers, Karel Allegaert, Thierry Voet, Jan Deprest, Joris Vriens, Jaan Toelen, Lambertus van den Heuvel, Elena Levtchenko. Journal of the American Society of Nephrology. Accepted on 22 december 2015.


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7. Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. E Peters, Stefania Geraci, S Heemskerk, MJ Wilmer, A Bilos, B Kraenzlin, N Gretz, P Pickkers, and R Masereeuw. British Journal of Pharmacology. 172(20):4932-45. October 2015.

10.1111/bph.13261


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8. Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy. Lauren Scarfe, Aleksandra Rak-Raszewska, Stefania Geraci, Darsy Darssan, Jack Sharkey, Jiaguo Huang, Neal C. Burton, David Mason, Parisa Ranjzad, Simon Kenny, Norbert Gretz, Raphaël Lévy, B. Kevin Park, Marta García-Fiñana, Adrian S. Woolf, Patricia Murray & Bettina Wilm. Scientific Reports, Vol 5, Article number: 13601. September 2015.

DOI:10.1038/srep13601


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9. Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Henricus A.M. Mutsaersa, Pedro Caetano-Pintoa, Andries E.M. Seegersa, Anita C.A. Dankersa, Petra H.H. van den Broeka, Jack F.M. Wetzelse, Jan A.J.G. van den Brande, Lambertus P. van den Heuvel, Joost G. Hoenderopb, Martijn J.G. Wilmera, Rosalinde Masereeuw.Toxicology in Vitro, Vol 29 (7) pp1868-1877. 2015.

DOI:10.1016/j.tiv.2015.07.020


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10. The use of lineage tracing to study kidney injury and regeneration. Paola Romagnani, Yuval Rinkevich and Benjamin Dekel.Nature Reviews Nephrology, Vol 11 pp420-431. 2015.

doi:10.1038/nrneph.2015.67


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11. Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. James Heslop, Thomas Hammond, Ilaria Santeramo, Agnes Tort Piella, Isabel Hopp, Jing Zhou, Roua Baty, Enrique Graziano, Bernabe Proto Marco, Alexis Caron, Patrik Skold, Peter Andrews, Melissa Baxter, David Hay, Junnat Hamdam, Michaela Sharpe, Sara Patel, David Jones, Jens Reinhardt, Erik Danen, Rui Ben-David, Glyn Stacey, Petter Bjorquist, Jacqueline Piner, John Mills, Cliff Rowe, Giovanni Pellegrini, Swaminathan Sessthu, Daniel Antoine, Michael Cross, Trish Murray, Dominic Williams,Neil Kitteringham, Chris Goldring & Kevin Park.Stem Cell Translation Medicine, Vol 4 (4) pp389-400. 2015.

DOI:10.5966/sctm.2014-0110


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12. Kidney stem cells in development, regeneration and cancer. Klaudyna Dziedzica, Oren Pleniceanua & Benjamin Dekel. Seminars in Cell Biology & Development Biology, Vol 36 pp57-65. 2014.

doi:10.1016/j.semcdb.2014.08.003


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13. Automatic artifact removal from GFR measurements. Anatoli Shmarlouski, Yuri Shulhevich, Stefania Geraci , Jochen Friedemann,Norbert Gretz, Sabine Neudecker, Juergen Hesser, Dzmitry Stsepankour.Biomedical Signal Processing and Control, Vol 14 pp30-41. 2014.

DOI:10.1016/j.bspc.2014.06.010


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12. A Pilot Study to Assess the Feasibility of Transcutaneous Glomerular Filtration Rate Measurement Using Fluorescence-Labelled Sinistrin in Dogs and Cats. Sarah Steinbach, Nora Krolop, Sellyn Strommer, Zeneida Herrera-Pérez, Stefania Geraci, Jochen Friedemann, Norbert Gretz, , Reto Neiger.PLOS One, November 2014 2014.

DOI:10.1371/journal.pone.0111734


Current Opinion in Organ Transplantation Cover Picture

14. Using stem and progenitor cells to recapitulate kidney development and restore renal function.
Patricia Murray & Adrian Woolf.
Current Opinion in Organ Transplantation 2014. Vol 19: (2): pp 140-144.

DOI: 10.1097/MOT.0000000000000052


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15. Transcutaneous assessment of glomerular filtration rate.
Stefania Geraci, Zeneida Herrera-Perez, Jiaguo Huang
, Stefanie Weinfurter, Sabine Neudecker, Yuri Shulhevich, Jochen Friedemann, Johannes Pill, Norbert Gretz. Studies in health technology and informatics. Vol 200: Pp:105-10. Aug 2014.

DOI: 10.3233/978-1-61499-393-3-105 (Abstract only)


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16. Concise Review: Stem/Progenitor Cells for Renal Tissue Repair: Current Knowledge and Perspectives.
Shikhar Aggarwal
, Aldo Moggio,Benedetta Bussolati. Stem Cells Translational Medicine 2013. Vol 2: pp1011-1019

DOI: 10.5966/sctm.2013-0097 (Abstract only)


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17. The self-renewal of mouse embryonic stem cells is regulated by cell–substratum adhesion and cell spreading.
Patricia Murray, Marina Prewitz, Isabel Hopp, Nicola Wells, Haifei Zhang, Andrew Cooper, Kristina L Parry, Robert Short, Daniel Antoine & David Edgar. The International Journal of Biochemistry & Cell Biology Vol 45: (11): pp 2698-2705. 2013.

DOI: 10.1016/j.biocel.2013.07.001


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18. Reliability of Transcutaneous Measurement of Renal Function in Various Strains of Conscious Mice.
Daniel Schock-Kusch, Stefania Geraci, Esther Ermeling, Yury Shulhevich, Carsten Sticht, Juergen Hesser, Dzmitry Stsepankou, Sabine Neudecker, Johannes Pill, Roland Schmitt, Anette Melk. PLOS One Vol 8: (8) e71519. Aug 2013.

DOI: 0.1371/journal.pone.0071519 Paper pdf


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19. The emerging role of MRI in quantitative renal glomerular morphology.
Kevin Bennett, John Bertram, Scott Beeman, Norbert Gretz. Americal Journal of Physiology, Renal Physiology. May 15, 2013; 304(10): F1252–F1257.

DOI: 10.1152/ajprenal.00714.2012


The International Journal of Biochemistry & Cell Biology Cover Picture

20. Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates.
Laurence Glennon-Alty, Rachel Williams, Simon Dixon, & Patricia Murray. Acta Biomaterialia. Vol 9: (4): pp 6041-6051.

DOI: 10.1016/j.actbio.2012.12.007 Paper pdf



Review Articles

Clinical Kidney Journal icon

1. Extracellular vesicles in the urine: markers and mediators of tissue damage and regeneration. Andrea Ranghino, Veronica Dimuccio, Elli Papadimitriou and Benedetta Bussolati.Clinical Kidney Journal, December 2014.

DOI:0.1093/ckj/sfu136


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2. Human Urine as a Noninvasive Source of Kidney Cells
Fanny Oliveira Arcolino, Agnès Tort Piella, Elli Papadimitriou, Benedetta Bussolati
, Daniel J. Antonie, Patricia Murray, Lamberthus van den Heuvel and Elena Levtchenko. Stem Cells International December 2014. Article ID 362562

Link to Review



Conference Contributions

1. Studying the effect of induced expandable human kidney progenitor cells on renal function using transcutaneous assessment. Zeneida Herrera-Pérez, Pleniceaneu O, Omer D, Dekel B, Gretz N. Abstract Journal of American Society of Nephrology 26, November 2015: 3-1140.


2. Analysis of exogenous near infrared fluorescent markers for the transcutaneous measurement of glomerular filtration rate. Jiaguo Huang . Poster Presentation at American Society of Nephrology Kidney Week 2015 Annual Meeting, San Diego USA, November 2015.


3. The role of CD133 molecule in renal papillary cells and its possible involvement in Wnt signaling and cellular senescence prevention. Elli Papadimitriou. Poster Presentation at American Society of Nephrology Kidney Week 2015 Annual Meeting, San Diego USA, November 2015.


5. Cetuximab prevents methotrexate-induced nephrotoxicity in vitro through epidermal growth factor-dependent signaling. Amer Jamalpoor, Pedro Caetano-Pinto, Janneke Ham, Martijn JG Wilmer, Carla van Herpen, R. Masereeuw. Oral Communication at Dutch Medicines Days, Ede, the Netherlands, 5-7 October 2015.


6. Developing novel in vitro models to investigate the mechanistic basis of mitochondrial dysfunction in adefovir and tenofovir induced renal injury. Agnes Tort Piella. Oral Communication at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


7. Cetuximab prevents methotrexate-induced nephrotoxicity in vitro through epidermal growth factor-dependent signaling. Pedro Caetano-Pinto, Amer Jamalpoor, Janneke Ham, Martijn JG Wilmer, Carla van Herpen, Rosalinde Masereeuw. Poster Presentation at 3rd NephroTools International Conference, Liverpoo1, United Kingdom, September 2015.


8. Effect of human kidney-derived cells on renal function in a cisplatin-induced kidney injury model. Zeneida Herrera Pérez. Oral Communication and Poster Presentaton at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


9. Novel Biomaterials for kidney stem cell differentiation. Isabel Hopp. Oral Communication and Poster Presentaton at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


10. Plasma Polymer coatings to direct kidney stem cell differentiation. Isabel Hopp. Poster Presentaton at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


11. Folic acid induced renal injury as a model to examine renoprotective effects of human derived kidney fetal stem/progenitor cells. Chiara Mari. Poster Presentation and Oral communication at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


12. Modulation of CD133 expression and role of urinary extracellular vesicles in cisplatin-induced renal tubule damage. Elli Papadimitriou. Poster Presentation at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


13. Development of exogenous near infrared fluorescent markers for transcutaneous measurement of glomerular filtration rate. Jiaguo Huang. Poster Presentation at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


14. CD133 surface molecule and CD133 positive extracellular vesicles in kidney damage. Elli Papadimitriou. Oral Communication at 3rd NephroTools International Conference, Liverpool, United Kingdom, September 2015.


16. CD133: A Specific Marker Of Kidney Progenitor Cells?Ilaria Santeramo, Zeneida Herrera Perez, Lauren Scarf, Jack Sharkey, Arthur Taylor, Norbert Gretz, Patricia Murray, Bettina Wilm.Oral Communication at 3rd NephroTools International Conference, Liverpoo1, United Kingdom, September 2015


17. Cell-derived extracellular matrices for kidney tissue engineering and regenerative medicine. Valentina Magno. Poster Presentation and Oral Communication at 3rd NephroTools International Conference, Liverpoo1, United Kingdom, September 2015.


18. Investigating the functional profile of human derived foetal kidney cells using fluorescent based assays. Pedro Caetano-Pinto, Chiara Mari, Martijn JG Wilmer, Karen Price, Rosalinde Masereeuw. Oral Communication at 3rd NephroTools International Conference, Liverpoo1, United Kingdom, September 2015.


19. Assessing the effects of human kidney-derived cells in a cisplatin-induced active kidney injury model. Ilaria Santeramo, Zeneida Herrera Perez, Norbert Gretz, Patricia Murray & Bettina Wilm. Pediatric Nephrology Vol 30 (9) pp1556-15556. Meeting Abstract: O37 Published: September 2015 (embargoed for 1 year).


20. Preterm neonatal urine as a novel source of hightly potent kidney progenitor cells. Fanny Oliveira Arcolino, Silvia Zia, Katharina Held, Anke Raaijmakers, Joris Vriens, Karel Allegaert, Jan Deprest, Jaan Toelen, Lambertus Van Den Heuvel & Elena Levtchenko . Pediatric Nephrology Vol 30 (9) pp1555-15555. Meeting Abstract: O34 Published: September 2015 (embargoed for 1 year).


21. Gradient technologies for optimising biomaterials for cell screening. Andrew Michelmore, Isabel Hopp, Louise E. Smith, Endre Szili, Nico Voelcker, Krasimir Vasilev. Cytotherapy Vol 17 (6) ppS72-S72. Meeting Abstract: 244 Published: June 2015

doi:10.1016/j.jcyt.2015.03.553


23. Cell-derived extracellular matrices for kidney tissue engineering and regenerative medicine. Valentina Magno.Poster Presentation at 9th Center for Regenerative Therapies Dresden Summer Conference on Regenerative Medicine. Dresden, Germany. June 5, 2015.


24. Developing novel in vitro models to investigate the mechanistic basis of mitochondrial dysfunction in tenofovir -induced renal injury. Agnes Tort Piella. Oral Communication at BTS Annual Congress, Solihull, UK. April 2015


25. Novel Generation and Characterisation of Human Renal Progenitor/Stem Cell Lines. Chiara Mari. Poster Presentation at American Society Nephrology, Annual meeting, Kidney week, Philadelphia, USA. November 2014.


26. Undifferentiated Kidney Cells From Amniotic Fluid And Urine As Sources Of Podocytes. Fanny Oliveira Arcolino, Lambertus Van Den Heuvel, Sylvia Zia, Jaan Toelen, Patricia Murray, Joris Vriens, Elena Levtchenko. Meeting Abstract, Sept 2014. Pediatric Nephrology Vol 29 (9) pp 1690-1690. Meeting Abstract: P15 Published: September 2014 (embargoed for 1 year).


27.Transcutaneous GFR measurement as a tool for the development of animal models for therapeutic approaches. Zeneida Herrera Pérez. Oral Communication at 2nd NephroTools International Conference, Turin, Italy, September 2014.


28. Development of mechanism-based and physiologically relevant in vitro systems as predictive models of nephrotoxicity. Agnes Tort Piella. Poster Presentation at 2nd NephroTools International Conference, Turin, Italy, September 2014.


29. Novel Generation and Characterisation of Human Renal Progenitor/Stem Cell Lines. Chiara Mari. Oral Communication at 2nd NephroTools International Conference, Turin, Italy, September 2014.


30. Modulation of CD133 expression by cell damage and effect of CD133+ urinary extracellular vesicles. Elli Papadimitriou. Poster Presentation at 2nd NephroTools International Conference, Turin, Italy, September 2014.


31. Function and morphology of renal glomeruli. Stefania Geraci. Poster Presentation at 2nd NephroTools International Conference, Turin, Italy, September 2014.


32. Exogenous near infrared fluorescent markers for transcutaneous measurement of glomerular filtration rate. Jiaguo Huang. Oral Communication at 2nd NephroTools International Conference, Turin, Italy, September 2014.


33 Renal basement membrane ECM derived from proximal tubule cells for KPCs differentiation. Valentina Magno. Poster Presentation at 2nd NephroTools International Conference, Turin, Italy, September 2014.


34. A pilot study to assess the feasibility of transcutaneous indocyanine green clearance as liver function test in cats and dogs. S. Strommer, S. Steinbach, N. Krolop, Zeneida Herrera-Pérez, Norbert Gretz, R. Neiger. Oral Communication by S. Strommer at ECVIM-CA Congress, Mainz, Germany, September 2014.


35. Adult human renal papilla CD133+ stem/progenitor cells repair glycerol-induced kidney injury in mice. Shikhar Aggarwal. Oral Communication at 2nd FIRM Symposium, Girona, Spain, September 2014.


36. Characterization of Novel Polyacrylates and their kidney stem cell differentiation potential. Isabel Hopp. Poster Presentation at European Society for Biomaterials Meeting - Liverpool, UK. September 2014.


37. Kidney Stem/Progenitor Cells of Amniotic Fluid and Neonatal and Adult Urine. Fanny Oliveira Arcolino, Lambertus Van Den Heuvel, Sylvia Zia, Jaan Toelen, Elena Levtchenko. Meeting Abstract, Sept 2014. Molecular Therapy Vol 22 (Supplement 1) pp S184-S184. Meeting Abstract 479 from 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), May 2014 . Published: May 2014 (embargoed for 1 year).


38. Adult human renal papilla CD133+ stem/progenitor cells repair glycerol-induced kidney injury in mice. Shikhar Aggarwal. Oral Communication at ABCD conference, Salerno. June 2014.


39. New concepts for the assessment of different renal functions. Jiaguo Huang. Oral Communication at NephroTools Workshop: Nephrology, Renal Injury Models and Methods for Evaluating Renal Function, Heidelberg, Germany, June 2014.


40. Fetal Renal Stem Cells Attenuate Ischemic Injury in the Rat Kidney. Marina da Cunha, Silvia Zia, Fanny Oliveira Arcolino, Elena Levtchenko, Jan Deprest, Jaan Toelen. Meeting Abstract, Sept 2014. Molecular Therapy Vol 22 (Supplement 1) pp S275-S275. Meeting Abstract 713 from 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), May 2014 . Published: May 2014 (embargoed for 1 year).


41. Kidney stem cell differentiation on Novel Polyacrylates. Isabel Hopp. Poster Presentation at Mesenchymal Stem Cell Workshop - Birmingham, UK – Dec 2013


42. Urinary loss of renal epithelial cells in nephropathic cystinosis. Ekaterina Ivanova Fanny Oliveiro Arcolino, Laura Giardino, Maria Pia Rastaldi, Lambertus Van Den Heuvel, Elena Levtchenko. Meeting Abstract, August 2013. Pediatric Nephrology Vol 28 (8) pp 1373-1374. Meeting Abstract: August 2013.


43. Investigating the pharmacological properties of bioproducts from kidney stem/progenitor cells. Elli Papadimitriou, Alessia Brossa, Veronica Dimuccio, Aldo Moggio, Benedetta Bussolati. Poster presented by Elli at the 1st Nephrotools Conference, Liverpool, July 2013.

Poster Presentation


44. Preliminary steps for the establishment of Cisplatin-induced kidney injury model in immunodeficient rats. Zeneida Herrera Pérez. Poster Presentation at the 1st Nephrotools Conference, Liverpool, July 2013.


45. Development of FITC-labeled hydrophilic polymers as exogenous agents for measurement of glomerular filtration rate. Jiaguo Huang. Poster Presentation at the 1st Nephrotools Conference, Liverpool, July 2013.


46. Novel Polyacrylates for kidney stem cell differentiation. Isabel Hopp. Poster Presentation at the 1st Nephrotools Conference, Liverpool, July 2013.


47. Extreme makeover: converting one cell into another. Klaudyna Dziedzic, Dorit Omer, Orit Harari-Steinberg, Benjamin Dekel. Poster presented by Klaudia at the 1st Nephrotools Conference, Liverpool, July 2013.

Poster Presentation


48. Adult human renal papilla CD133+ stem/progenitor cells repair glycerol-induced kidney injury in mice. Shikhar Aggarwal. Oral Communication at the 1st Nephrotools Conference, Liverpool, July 2013.


49. Development and Characterization of Novel Polyacrylates and their ability to differentiate kidney stem cells. Isabel Hopp. Poster Presentation17th Nephrogenesis Workshop, Edinburgh, UK. June 2013.


50. Future developments in kidney imaging and function assessment. Stefania Geraci. Presentation at 16th European Nephrogenesis Workshop, Liverpool June 2012.


51. Transcutaneous measurement of renal function in conscious mice.Andrea Schreiber, Yury Shulhevich , Stefania Geraci, Juergen Hesser, Dzmitry Stsepankou, Sabine Neudecker, Stefan Koenig, Ralf Heinrich, Friederike Hoecklin, Johannes Pill, Jochen Friedemann, Frank Schweda, Norbert Gretz, Daniel Schock-Kusch Poster presented by Stefania at 49th Congress of the European Renal Association and European Dialysis and Transplant Association 2012 24 - 27 May 2012, FP093.

Poster Presentation


52. Characterization of Novel Polyacrylates and their potential for kidney stem cell differentiation. Isabel Hopp. Presentation at ACMM 22 / APMC 10 / ICONN 2012 – Perth, Australia. February 2012

Patents

1. Novel tricarbocyanine-cyclodextrin(s) conjugates and uses thereof. Cyanagen S.r.l., L Della Ciana,Norbert Gretz, R Perciaccante, F Rodeghiero, Stefania Geraci, Jiaguo Huang, Zeneida Herrera Pérez, S Weinfurter: Priority: May 16, 2014: IT TO20140391. Date of publication: Nov 18, 2015: Publication number: EP 2 944 326 A1.